Aniston will play be in an overburdened suburban relationship who decide to recapture the fun of their youth.
The Friends actor is in talks with STXfilms for the untitled comedy with director Sophie Goodhart ( My Blind Brother).
The project is set up at Safehouse Pictures with Joby Harold and Tory Tunnell producing. Matt Schwartz and Douglas Banker are executives producing.
Goodheart previously worked with the Safehouse team on My Blind Brother starring Adam Scott, Jenny Slate and Nick Kroll.
STX is hoping to tap into the same audience as it did last year with “Bad Moms,” which grossed $113 million domestically.
Aniston is no stranger to adult comedies.“Horrible Bosses” movies, “We’re the Millers,” “She’s Funny That Way,” “Life of Crime,” “Cake,” and “Office Christmas Party” are just the ones she’s starred in, in recent years.